PhD Scholar
Department of Biotechnology and Bioinformatics
Jaypee University of Information Technology (JUIT)

I am a research scholar working in the field of computational biology. My research area comprises of genetic and functional aspects implicated in DNA repair, associated disorders and pathways. My main focus is on the quantitative genetic study of the genes involved in several mechanisms of repair, analysis of SNPs and other genetic variations and also looking at the effect of these mutations at structural level.

Academic Profile
Academic Achievements
Research Interests
Computational biology, systems biology, drug desiging, structural biology, functional genomics, database development, protein-protein interactions, pathway analysis, quantitative genetic association studies and identification and analysis of single nucleotide polymorphisms.

  • B.Sc. Project: “Studying and analyzing in silico drug designing tools and resources”
  • M.Sc. Project: “In silico structure based drug designing for dopamine receptor D2 (DRD2), a therapeutic target for schizophrenia”
  • A year diploma in Information Technology from National Institute of Information Technology (NIIT), Yamuna Nagar, Haryana, India
  • Summer Internship from Indian Institute of Science Education and Research (IISER), Mohali, India for the period May-July, 2011
  • Training in MS Office, C, C++ and other basics in computer applications from Kips India
  • Training on computational drug designing from DNA Research Centre, Zirakpur, Panjab, Inida
  • Training in programming languages like C++ and C# from Hartron, Haryana, India
  • Training from ADI Biosolutions, Mohali, India on target identification, molecular modeling and in silico structure based drug designing

Research Experience
  • Experience in handling numerous biological problems with sequence, structure and phylogenetic information using different tools and servers
  • Dealing with complex datasets, analyzing and applying different integrative approaches from past 5-6 years
  • Languages : C, C++, C#, Java, Perl, PHP, JavaScript
  • DBMS Packages : SQL SERVER 2005, MySQL
  • Operating System: Windows 98, 2000, XP, 7, Solaris
  • Web Designing : HTML, XML, DBMS and Data Structures
  • Developed a database, DRGAS: DNA Repair Genetic Association Studies, accessible at

  • Manika Sehgal and Tiratha Raj Singh, Identification and analysis of biomarkers for mismatch repair proteins: A bioinformatic approach, JNSBM. 3 (2012) 139-146
  • Manika Sehgal and Tiratha Raj Singh, DR-GAS: A database of functional genetic variants and their phosphorylation states in human DNA repair systems, DNA Repair. 16 (2014) 97-103
  • Manika Sehgal and Tiratha Raj Singh, Systems biology approach for mutational and site-specific structural investigation of DNA repair genes for xeroderma pigmentosum, Gene . (2014) [In Press]

Conferences/ Symposia/ Workshops
  • Presented paper entitled "Quantitative Genetic Analysis of DNA Repair Genes Implicated in Xeroderma Pigmentosum" at The Third International Federation for Information Processing (IFIP) International Conference on Bioinformatics in Maulana Azad National Institute of Technology (MANIT), Bhopal, Madhya Pradesh, INDIA from 23-26, September 2013 (Oral Presentation)
  • Presented paper entitled "Identification and Analysis of Biomarkers for Mismatch Repair Proteins: A Bioinformatic Approach" at The International Interdisciplinary Science Conference (I-ISC, 2011) on Bioinformatics: An interface between Computer Science and Biology in Jamia Millia Islamia, New Delhi, INDIA from 15-17, November 2011 (Oral Presentation)
  • National Symposium on The Recent Trends in Bioinformatics held at Panjab University, Chandigarh, INDIA on 26th April, 2011
  • Workshop on Data Mining and Parallel Computing jointly organized by Jaypee University of Information Technology & University of Florida at Waknaghat, Solan, INDIA from 2-5, August, 2011
  • A Bioinformatics workshop jointly organized by University of Nebraska, Omaha, USA and JUIT, Waknaghat, HP, INDIA from 8-10, May, 2013
  • National workshop on In silico approaches for designing bioactive peptides held at IMTECH, Chandigarh, INDIA from 18-21, October 2011
  • Resource Person for scripting languages in summer training at Jaypee University, Waknaghat, (HP), INDIA from June-July, 2013
  • Resource Person in The 19th Workshop on Pathways and System-Integrated Approaches at Bioinfo Centre, Himachal Pradesh University (HPU), Shimla (HP), INDIA from 16-19, September, 2013

Leadership Activities/ Appointments
  • Resource Person for teaching and taking labs of scripting languages in summer training held at Jaypee University of Information Technology, Solan, (H.P.), India from June-July, 2013
  • Resource Person in “The 19th Workshop on Pathways and System-Integrated Approaches” at Bioinformatics Centre, Himachal Pradesh University (HPU), Shimla (H.P.), India from 16-19, September, 2013
  • Member of The Woman Study Cell of M.L.N. College, Yamunanagar, Kurukshetra University Kurukshetra

Listening to music, dancing, swimming, skating and reading books.

Go to Top of the Page